Compound Comparisons
TB-500 vs BPC-157 After the FDA Move: What's Changed (and What Hasn't)
Very different regulatory futures. Here's what the FDA action actually changes — and what it doesn't
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Vivy editorialHealth intelligence, in context
The longevity brief
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Guides, comparisons, regulatory notes, and product thinking for people who want to understand the context around their health decisions.
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Compound ComparisonsPeptidesTracking & BloodworkProtocol GuidesRegulatory
Current dispatchApril 29, 2026
Reading ledger
More from the brief
10 notes
Peptides
TB-500 vs BPC-157: What the Research Actually Says
On April 22, 2026, the FDA removed BPC-157 and TB-500 from Category 2 of the 503A Bulk Drug Substances List. The same week, mainstream outlets ran back-to-back pieces questioning the safety of unregulated peptides. Here's what the evidence actually supports, what the regulatory shift means in practice, and what the July PCAC review could change.
April 29, 20265 min read
Tracking & Bloodwork
How to Build a Bloodwork Baseline Before Changing Compounds
If your labs move after you change a compound, supplement, or GLP-1 plan, the hard question is not just what changed. It is whether the result changed enough to mean something.
April 29, 20269 min read
Peptides
How to Read Peptide Claims When Human Evidence Is Thin
A peptide claim can sound scientific and still be several steps away from human evidence. Use this checklist to spot evidence gaps before hype drives your decisions.
April 27, 20269 min read
Compound Comparisons
TB-500 vs BPC-157: The Healing Peptide Showdown (What the Research Actually Says)
BPC-157 and TB-500 are the two most-stacked healing peptides. But they work differently, have different risk profiles, and one has a much murkier regulatory status. Heres what the science says.
April 20, 20267 min read
Peptides
GHK-Cu: The Copper Peptide That Connects Wound Healing to Longevity Science
Few compounds in the longevity research space have as long a publication history — or as many contradictory claims made about them — as GHK-Cu (glycyl-histidyl-lysine, copper complex).
April 19, 20267 min read
Peptides
TB-500 and BPC-157: How to Stack Healing Peptides Without Guessing
If you've spent any time in peptide-focused corners of Reddit, Hacker News, or longevity forums, you've seen the names come up again and again: TB-500 and BPC-157 .
April 19, 20267 min read
Peptides
The Complete Ipamorelin & CJC-1295 Stack Guide
Two growth hormone peptides — Ipamorelin and CJC-1295 — are often stacked for complementary GH pathway stimulation. Here is what the science says, how each compound works, and how to track your protocol precisely.
April 19, 20267 min read
Protocol Guides
How to Track Clinician-Directed Protocol Results
A practical, non-instructional checklist for tracking symptoms, labs, and wellness context for clinician discussions.
April 14, 202612 min read
Compound Comparisons
Semaglutide vs Tirzepatide vs Retatrutide: Head-to-Head Comparison
Three compounds. Different mechanisms. The same goal. Here's what the literature actually says about weight loss, side effects, half-life, and sustainability.
April 14, 202615 min read
Regulatory
The Peptide FDA Status Tracker: What Changed in 2025–2026
The regulatory landscape for peptides shifted significantly over the past 18 months. Here's a factual, non-advocacy breakdown of what happened.
April 14, 202610 min read