Peptides / Dihexa
Dihexa
(Dihexa, P-631, Angiotensin IV analog)T3peptidepreclinical
Biomarker Effects
HGF
↑ moderate
c-Met/HGF agonism
Synaptic density
↑ moderate
Promotes synaptogenesis
BDNF
↑ small
Neurotrophic signaling
Cognitive performance
↑ moderate
Supports memory formation
Oxidative stress
↓ small
Neuroprotective antioxidant effects
TNF-alpha
↓ small
Anti-inflammatory signaling
IL-6
↓ small
Cytokine modulation
Neuroinflammation
↓ moderate
Reduces inflammatory glial signaling
NGF
↑ small
Neurotrophic support
Neuroplasticity
↑ moderate
Supports synaptic remodeling
Dopamine
↑ small
Neurotransmitter support
Acetylcholine
↑ small
Cholinergic signaling
Memory score
↑ small
Improves memory formation
Reaction time
↓ small
Improves processing speed
Anxiety score
↓ small
Neurotrophic effects
Synaptogenesis
↑ moderate
Enhances synapse formation
Dosing & Pharmacokinetics
Typical Dose10 mg
Frequencydaily
Routeclinician-directed
Half-Life2.0 days
Safety & Evidence
Dihexa is a synthetic peptide derivative of angiotensin IV that has shown neuroregenerative and cognitive-enhancing effects in preclinical studies. Not FDA-approved.
Sources
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