Peptides / MK-677 (Ibutamoren)
MK-677 (Ibutamoren)
(Ibutamoren, L-163,191, MK-677)T2peptideliterature
Biomarker Effects
IGF-1
↑ large
Ghrelin receptor agonist
Fasting glucose
↑ small
Transient insulin resistance
Growth hormone
↑ large
Stimulates pituitary GH release
IGFBP-3
↑ moderate
GH-mediated binding proteins
Cortisol (AM)
↓ small
Improves sleep architecture
Sleep efficiency
↑ moderate
Improves sleep quality
Melatonin (endogenous)
↓ small
Circadian regulation
Appetite
↑ moderate
Ghrelin agonism
Water retention
↑ small
GH-related fluid retention
HbA1c
↑ small
May worsen glycemic control
Fasting insulin
↑ small
Insulin resistance
Edema
↑ small
GH-related fluid retention
Ghrelin
↑ large
Ghrelin receptor agonism
Dosing & Pharmacokinetics
Typical Dose12.5 mg
Frequencydaily
Routeclinician-directed
Half-Life6 hr
Safety & Evidence
MK-677 is an oral ghrelin mimetic (GHS) that stimulates GH and IGF-1 secretion. Not FDA-approved. Available as oral tablet.
Sources
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